Bio

Research in the Hall Lab is focused on the identification and characterization of genes and signaling pathways that determine susceptibility to skin cancer. We are especially interested in how cells respond to environmental stress (such as solar UVB-induced DNA damage) when making the decision to live or to trigger regulated cell death.

Publications

• C/EBPβ deficiency enhances keratinocyte apoptosis after UVB-induced DNA damage via regulation of the type I IFN and TNF responses , Frontiers in Cell Death (2025)
• Conditional knockout of C/EBPβ in epidermis results in dysregulated lipid biosynthesis and a defect in skin barrier function , PLoS ONE (2025)
• Mutant Nrf2E79Q enhances the promotion and progression of a subset of oncogenic Ras keratinocytes and skin tumors , Redox Biology (2024)
• C/EBPβ deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors , Innate Immunity (2023)
• TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA , Nucleic Acids Research (2021)
• C/EBPβ suppresses keratinocyte autonomous type 1 IFN response and p53 to increase cell survival and susceptibility to UVB-induced skin cancer , Carcinogenesis (2019)
• C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event , Cell Death & Disease (2018)
• Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes , Nanotoxicology (2018)
• Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes , Cell Death and Disease (2015)
• C/EBPα regulates CRL4Cdt2-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint , Cell Cycle (2014)